Asian Journal of Organic Chemistry · 2021 · 15 citations · 47 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistryHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsOrganic SynthesisHeteroaromatic CompoundsHeterocycle FunctionalizationMedicinal HeterocyclesMild Reaction ConditionsQuinoxaline ChemistryQuinoxaline Synthesis
Abstract A new method for the difluoroalkylation of heteroaromatic compounds has been developed by employing readily available difluoroalkyl carboxylic acids. This silver‐catalyzed reaction proceeds under mild conditions and affords a broad range of difluoroalkylated heteroarenes in moderate to good yields, including pyridines, pyrimidines, pyrazines, quinolines, quinoxalines as well as bioactive compounds.
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Practical and innate carbon–hydrogen functionalization of heterocycles
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Innate C-H trifluoromethylation of heterocycles
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