Berberine inhibits gastric cancer development and progression by regulating the JAK2/STAT3 pathway and downregulating IL-6

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram et al. · CA A Cancer Journal for Clinicians · 2018 · 87.7K citations · Full text

Medicine, Oncology, Cancer Epidemiology +16

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

Hyun Woo Jeong, Kuan Chi Hsu, Joo-Won Lee et al. · American Journal of Physiology-Endocrinology and Metabolism · 2009 · 444 citations

Life Sciences, Immunology, Pharmacology +17

IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metastasis of gastric cancer via JAK2/STAT3 signaling pathway

Xiongyan Wu, Tao Pan, Quan Zhou et al. · Oncotarget · 2017 · 395 citations · Full text

Medicine, Cancer Biology, Oncology +17

Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells

Sudheer K. Mantena, Som D. Sharma, Santosh K. Katiyar · Molecular Cancer Therapeutics · 2006 · 351 citations · Full text

Medicine, Oncology, Pharmacology +15

FOXC2 Expression Links Epithelial–Mesenchymal Transition and Stem Cell Properties in Breast Cancer

Brett G. Hollier, Agata A. Tinnirello, Steven J. Werden et al. · Cancer Research · 2013 · 286 citations · Full text

Medicine, Cell Biology, Oncology +17