Concepedia

Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis

Mohmad Alsabani, Simon T. Abrams, Zhenxing Cheng, Ben Morton, Steven Lane, Samar Alosaimi, Weiping Yu, Guozheng Wang, Cheng‐Hock Toh

British Journal of Anaesthesia · 2021 · 99 citations · 41 references

Open access

Concepts

Veterinary MedicineImmunologyPharmacologyInflammationInnate ImmunitySepsisCytokine BiologyCytokine-mediated PathologyImmune-mediated InjuryInflammatory SignalingSepsis PathophysiologySeptic ShockInflammatory Lung InjuryMonocyte Chemoattractant Protein-1Sepsis-associated InflammationSepsis-associated Lung InjurySepsis-induced Organ FailureSepsis-induced Tissue InjuryThrombosis In Sepsis

References

41

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Mervyn Singer, Clifford S. Deutschman, Christopher W. Seymour et al. · JAMA · 2016 · 28K citations · Full text

Veterinary Medicine, Immunology, Pathobiology +17

Neutrophil Extracellular Traps Kill Bacteria

Volker Brinkmann, Ulrike Reichard, Christian Goosmann et al. · Science · 2004 · 10.1K citations

Life Sciences, Immunology, Microbiology +17

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

Kristina E. Rudd, Sarah Charlotte Johnson, Kareha M Agesa et al. · The Lancet · 2020 · 7.7K citations · Full text

Public Health, Infectious Diseases, Epidemiologic Methods +14

Neutrophil emigration in the skin, lungs, and peritoneum: different requirements for CD11/CD18 revealed by CD18-deficient mice.

PubMed · 1997 · 7.1K citations · Full text

Life Sciences, Immunology, Pathology +15

Extracellular DNA traps promote thrombosis

Tobias A. Fuchs, Alexander Brill, Daniel Duerschmied et al. · Proceedings of the National Academy of Sciences · 2010 · 2.4K citations · Full text

Medicine, Immunology, Pathobiology +17