Human amniotic membrane extracellular matrix scaffold for dental pulp regeneration <i>in vitro</i> and <i>in vivo</i>

Abstract

The 30 mg/ml HAM ECM scaffold had optimal physical properties and better supported hDPSC migration. The HAM ECM scaffold did not interfere with formation of pulp-like tissue and revascularization within the root canal when employed as both cell-free and cell-loaded scaffold. These results highlight the potential of HAM ECM membrane for further investigations in regenerative endodontics.