Concepedia

MicroRNA-155-5p promotes neuroinflammation and central sensitization via inhibiting SIRT1 in a nitroglycerin-induced chronic migraine mouse model

Qianwen Wen, Yunfeng Wang, Qi Pan, Ruimin Tian, Dunke Zhang, Guangcheng Qin, Jiying Zhou, Lixue Chen

Journal of Neuroinflammation · 2021 · 122 citations · 47 references

DOIFull text

Open access

Abstract

These data demonstrate that upregulated miR-155-5p in the TNC participates in the central sensitization of CM. Inhibiting miR-155-5p alleviates neuroinflammation by activating SIRT1 in the TNC of CM mice.

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