Increased Risk of Hospital Admission for Asthma in Children From Short-Term Exposure to Air Pollution: Case-Crossover Evidence From Northern China

Abstract

<b>Background:</b> Previous studies suggested that exposure to air pollution could increase risk of asthma attacks in children. The aim of this study is to investigate the short-term effects of exposure to ambient air pollution on asthma hospital admissions in children in Beijing, a city with serious air pollution and high-quality medical care at the same time. <b>Methods:</b> We collected hospital admission data of asthma patients aged ≤ 18 years old from 56 hospitals from 2013 to 2016 in Beijing, China. Time-stratified case-crossover design and conditional Poisson regression were applied to explore the association between risk of asthma admission in children and the daily concentration of six air pollutants [particulate matter ≤ 2.5 μm (PM_2.5), particulate matter ≤ 10 μm (PM₁₀), sulfur dioxide (SO₂), nitrogen dioxide (NO₂), carbon monoxide (CO), and ozone (O₃)], adjusting for meteorological factors and other pollutants. Additionally, stratified analyses were performed by age, gender, and season. <b>Results:</b> In the single-pollutant models, higher levels of PM_2.5, SO₂, and NO₂ were significantly associated with increased risk of hospital admission for asthma in children. The strongest effect was observed in NO₂ at lag06 (<i>RR</i> = 1.25, 95%CI: 1.06-1.48), followed by SO₂ at lag05 (<i>RR</i> = 1.17, 95%CI: 1.05-1.31). The robustness of effects of SO₂ and NO₂ were shown in two-pollutant models. Stratified analyses further indicated that pre-school children (aged ≤ 6 years) were more susceptible to SO₂. The effects of SO₂ were stronger in the cold season, while the effects of NO₂ were stronger in the warm season. No significant sex-specific differences were observed. <b>Conclusions:</b> These results suggested that high levels of air pollution had an adverse effect on childhood asthma, even in a region with high-quality healthcare. Therefore, it will be significant to decrease hospital admissions for asthma in children by controlling air pollution emission and avoiding exposure to air pollution.