Glutamine promotes antibiotic uptake to kill multidrug-resistant uropathogenic bacteria

Xianliang Zhao, Zhuang‐Gui Chen, Tian‐Ci Yang, Ming Jiang, Jie Wang, Zhi-xue Cheng, Manjun Yang, Jiaxin Zhu, Tiantuo Zhang, Hui Li,

Science Translational Medicine · 2021 · 237 citations · 32 references

Concepts

Abstract

elevated antibiotic resistance in antibiotic-sensitive strains. In addition, glutamine retarded the development of ampicillin resistance. These results may facilitate future development of effective approaches for preventing or managing chronic, multidrug-resistant bacterial infections, bacterial persistence, and difficult-to-treat bacterial biofilms.

References

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