Gemcitabine-facilitated modulation of the tumor microenvironment and PD-1/PD-L1 blockade generate a synergistic antitumor effect in a murine hepatocellular carcinoma model

Clinical safety and activity of pembrolizumab in patients with malignant pleural mesothelioma (KEYNOTE-028): preliminary results from a non-randomised, open-label, phase 1b trial

Evan Alley, Juanita Lopez, Armando Santoro et al. · The Lancet Oncology · 2017 · 489 citations

Malignant Pleural Mesothelioma, Medicine, Clinical Safety +6

Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death

Kazukuni Hayashi, Fotis Nikolos, Y. C. Lee et al. · Nature Communications · 2020 · 258 citations · Full text

Gemcitabine reduces MDSCs, tregs and TGFβ-1 while restoring the teff/treg ratio in patients with pancreatic cancer

Emma Eriksson, Jessica Wenthe, Sandra Irenaeus et al. · Journal of Translational Medicine · 2016 · 210 citations · Full text

Effect of gemcitabine on immune cells in subjects with adenocarcinoma of the pancreas

Janet M.D. Plate, Aileen E. Plate, Susan Shott et al. · Cancer Immunology Immunotherapy · 2005 · 174 citations · Full text

Immune Cells, Pancreatic Cancer, Medicine +7

Changes in the immune cell population and cell proliferation in peripheral blood after gemcitabine-based chemotherapy for pancreatic cancer

Yuki Homma, K Taniguchi, Mitsuru Nakazawa et al. · Clinical & Translational Oncology · 2013 · 81 citations

Pancreatic Cancer, Medicine, Immunology +8