Concepedia

LIM Homeobox-2 Suppresses Hallmarks of Adult and Pediatric Liver Cancers by Inactivating MAPK/ERK and Wnt/Beta-Catenin Pathways

Nicola Mosca, Fatma Zohra Khoubai, Sandrine Fédou, Juan Carrillo-Reixach, Stefano Caruso, Álvaro Del Río-Álvarez, Emeric Dubois, Christophe Avignon, Nathalie Dugot‐Senant, Catherine Guettier,

Liver Cancer · 2021 · 14 citations · 35 references

DOIFull text

Open access

Abstract

Collectively, our findings demonstrate a tumor suppressive function of LHX2 in adult and pediatric liver cancers.

References

35

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

Ron Edgar · Nucleic Acids Research · 2002 · 13.5K citations · Full text

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Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets

Sandrine Boyault, David S. Rickman, Aurélien de Reyniès et al. · Hepatology · 2006 · 1.2K citations · Full text

Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

Alix de La Coste, Béatrice Romagnolo, Pierre Billuart et al. · Proceedings of the National Academy of Sciences · 1998 · 1.1K citations · Full text

<i>Lhx2</i>, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development

Forbes D. Porter, John Drago, Yang Xu et al. · Development · 1997 · 498 citations

Hepatic Stem-like Phenotype and Interplay of Wnt/β-Catenin and Myc Signaling in Aggressive Childhood Liver Cancer

Stefano Cairo, Carolina Armengol, Aurélien de Reyniès et al. · Cancer Cell · 2008 · 495 citations · Full text

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