Concepedia

New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and <i>in silico</i> studies

Hazem Elkady, Alaa Elwan, Hesham A. El‐Mahdy, Ahmed S. Doghish, Ahmed Ismail, Mohammed S. Taghour, Eslam B. Elkaeed, Ibrahim H. Eissa, Mohammed A. Dahab, Hazem A. Mahdy,

Journal of Enzyme Inhibition and Medicinal Chemistry · 2021 · 122 citations · 46 references

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Abstract

docking studies were also performed to get better insights into the possible binding mode of the target compounds with VEGFR-2 active sites.

References

46

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Tim R. Mosmann · Journal of Immunological Methods · 1983 · 55.6K citations

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Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)

J. Jean Cui, Michelle Tran‐Dubé, Hong Shen et al. · Journal of Medicinal Chemistry · 2011 · 922 citations · Full text

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Luminescent Biological Probes Derived from Ruthenium(II) Estradiol Polypyridine Complexes

Kenneth Kam‐Wing Lo, Terence Kwok‐Ming Lee, Jason Shing-Yip Lau et al. · Inorganic Chemistry · 2007 · 306 citations

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Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF‐<i>κ</i>B Suppression and NLRP3 Inflammasome Inhibition

Yuanyuan Ran, Wei Su, Fuhai Gao et al. · Oxidative Medicine and Cellular Longevity · 2021 · 222 citations · Full text

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Pharmacophore modeling and virtual screening studies for new VEGFR-2 kinase inhibitors

Kyungik Lee, Ki‐Woong Jeong, Yeonjoo Lee et al. · European Journal of Medicinal Chemistry · 2010 · 181 citations · Full text

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