Organic Letters · 2021 · 14 citations · 29 references
NanotherapeuticsEngineeringSynthetic PhotochemistryOrganic ChemistryChemistryNanomedicineMedicinal ChemistryTherapeutic NanomaterialsPhototoxicityIsoquinoline-fused PorphyrinsBioimagingChemodynamic TherapyPhotosensitizersRadiation OncologyMolecular ImagingHealth SciencesPhotochemistryIsoquinoline-fused Porphyrins 3Photodynamic TherapyPhotothermal TherapyPharmacologyRepresentative Nanoparticles
The synthesis of efficient porphyrin-based photosensitizers with intense near-infrared (NIR) absorption is in high demand for photodynamic therapy (PDT) but remains a challenging task. Herein we show the construction of a type of isoquinoline-fused porphyrins 3 and 4 with an impressive NIR-absorbing capacity. In light of the extraordinary singlet oxygen generation capabilities of 3 upon NIR irradiation, the representative nanoparticles (3a-NPs) assembled show excellent tumoricidal behavior with good biocompatibility in the phototherapeutic window (650–850 nm).
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