Advanced Science · 2021 · 10 citations · 0 references
MedicineEndocrinologyNeuroscienceBone MetabolismNeuroendocrinologyStem Cell BiologyAdipocyte DifferentiationAdipose TissueBone DevelopmentBone EndocrinologyBone FormationOsteogenesisAdipogenesis In Bone MarrowAutonomic Nervous System DysfunctionAutonomic Nervous System EffectsBone Marrow Mesenchymal Stem CellsBone Marrow-derived Mesenchymal Stromal CellsCell Fate Decision SignalingEstrogen MetabolismEstrogen Signaling In Bone
Autonomic Nervous System In article number 2100808 by Yan Zhang, Hui Xie, and co‐workers, osteocyte neuropeptide Y (NPY)‐dependent neuronal control of bone marrow mesenchymal stem/stromal cell (BMSC) fate decision is found. Osteocyte NPY promotes bone marrow adipogenesis at the expense of osteogenesis by BMSC. Osteocyte NPY production is controlled by autonomic nervous system (ANS). γ‐Oryzanol attenuates ANS dysregulation, NPY overproduction, and bone‐fat imbalance induced by aging and estrogen deficiency. [Image: see text]