Concepedia

In vivo validation and tissue sparing factor for acute damage of pencil beam scanning proton FLASH

Brita Singers Sørensen, Mateusz Sitarz, C. Ankjærgaard, Jacob Johansen, C.E. Andersen, Eleni Kanouta, Cathrine Overgaard, Cai Grau, P.R. Poulsen

Radiotherapy and Oncology · 2021 · 138 citations · 18 references

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Abstract

The normal tissue sparing effect of PBS proton FLASH was validated. The FLASH factor was quantified through full dose response curves.

References

18

Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice

Vincent Favaudon, Laura Caplier, Virginie Monceau et al. · Science Translational Medicine · 2014 · 1.3K citations · Full text

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

Pierre Montay‐Gruel, Kristoffer Petersson, Maud Jaccard et al. · Radiotherapy and Oncology · 2017 · 643 citations · Full text

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Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species

Pierre Montay‐Gruel, Munjal M. Acharya, Kristoffer Petersson et al. · Proceedings of the National Academy of Sciences · 2019 · 558 citations

Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System

Eric S. Diffenderfer, Ioannis I. Verginadis, Michele M. Kim et al. · International Journal of Radiation Oncology*Biology*Physics · 2020 · 447 citations · Full text

Experimental Set-up for FLASH Proton Irradiation of Small Animals Using a Clinical System

Annalisa Patriarca, Charles Fouillade, Michel Auger et al. · International Journal of Radiation Oncology*Biology*Physics · 2018 · 252 citations

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