Ginsenoside compound K acts via LRP1 to alleviate Amyloid β42-induced neuroinflammation in microglia by suppressing NF-κB

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

Wolfgang J. Streit, Heiko Braak, Qing‐Shan Xue et al. · Acta Neuropathologica · 2009 · 745 citations · Full text

Medicine, Neurobiology, Neuroscience +17

Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E

Steven W. Barger, Ashley Harmon · Nature · 1997 · 617 citations · Full text

Life Sciences, Neurobiology, Neuroscience +16

Microglial response to amyloid plaques in APPsw transgenic mice.

Sally A. Frautschy, Fusheng Yang, Michael Irrizarry et al. · PubMed · 1998 · 602 citations

Life Sciences, Neurobiology, Neuroscience +14

LRP1 is a master regulator of tau uptake and spread

Jennifer N. Rauch, Gabriel Luna, Elmer Guzman et al. · Nature · 2020 · 559 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +9

Intrathecal inflammation precedes development of Alzheimer's disease

E. Tarkowski · Journal of Neurology Neurosurgery & Psychiatry · 2003 · 505 citations · Full text

Life Sciences, Neurology, Neuroscience +17