Cyclosporine A augments the regenerative response after partial hepatectomy in the rat.

Abstract

Injury to the liver results in a regenerative response that is characterized by proliferation of both parenchymal and littoral cells. During orthotopic transplantation of the liver, the liver may be injured by ischemia during the harvesting procedure and by rejection in the posttransplant period. Cyclosporine A (CsA), a powerful immunosuppressive agent, is used routinely after orthotopic liver transplantation, and it thus seemed appropriate and important to study the effect of CsA on hepatic regeneration.