Our results are consistent with a model of neuropathic pain whereby peripheral nerve injury reduces NRG1-mediated inhibition of nociceptive signaling. Modulating NRG1 may have therapeutic potential for treating neuropathic pain.
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Prevalence of chronic pain with neuropathic characteristics in the general population
Didier Bouhassira, Michel Lantéri‐Minet, Nadine Attal et al. · Pain · 2007 · 1.7K citations · Full text
Neuregulin-1 Enhances Depolarization-Induced GABA Release
Ran‐Sook Woo, Xiao-Ming Li, Yanmei Tao et al. · Neuron · 2007 · 306 citations · Full text
Molecular Neuroscience, G Protein-coupled Receptor, Medicine +4