The Absorption and Distribution of a Chemotherapeutic Agent, P-7138 in Fishes

Abstract

The absorption of P-7138 by fishes and its distribution in their bodies were investigated. When eels, goldfish, yellowtails and abalones were bathed in P-7138 solution, the compound was distributed in the various tissues. The prompt absorption was observed in eels, mainly through the gills, even after bathing at low temperatures, for short time and at low concentrations. By oral administration to yellowtails the compound in all the body parts attained to the maximum levels 1 hour post-administration. The extinction of this compound from the fishes was comparatively rapid.