Extreme oceanographic events recorded in the Southern Benguela during the 1999-2000 summer season

Abstract

Pursuing effective and generalized strategies for modulating the electronic structures of atomically dispersed nanozymes with remarkable catalytic performance is exceptionally attractive yet challenging. Herein, we developed a facile "formamide condensation and carbonization" strategy to fabricate a library of single-atom (M₁-NC; 6 types) and dual-atom (M₁/M₂-NC; 13 types) metal-nitrogen-carbon nanozymes (M = Fe, Co, Ni, Mn, Ru, Cu) to reveal peroxidase- (POD-) like activities. The Fe₁Co₁-NC dual-atom nanozyme with Fe₁-N₄/Co₁-N₄ coordination displayed the highest POD-like activity. Density functional theory (DFT) calculations revealed that the Co atom site synergistically affects the d-band center position of the Fe atom site and served as the second reaction center, which contributes to better POD-like activity. Finally, Fe₁Co₁ NC was shown to be effective in inhibiting tumor growth both <i>in vitro</i> and <i>in vivo</i>, suggesting that diatomic synergy is an effective strategy for developing artificial nanozymes as novel nanocatalytic therapeutics.