Idiotypic vaccination with a murine anti-dsDNA antibody: phase I study in patients with nonactive systemic lupus erythematosus with nephritis. - Concepedia

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Idiotypic vaccination with a murine anti-dsDNA antibody: phase I study in patients with nonactive systemic lupus erythematosus with nephritis.

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References

1999

Year

François Spertini, Annette Leimgruber, Benoît Morel, M B Khazaeli, Kojiro Yamamoto, J.-M. Dayer, Richard H. Weisbart, M L Lee

Abstract

In patients with stable lupus nephritis, immunization with Mab 3E10 appears safe and can generate a significant antiidiotypic response. Idiotypic vaccination may be an approach to specific immunotherapy of autoimmune lupus nephritis.