A study of the role of cell-mediated immunity in bluetongue virus infection in sheep, using cellular adoptive transfer techniques.

Abstract

The transfer of thoracic duct lymphocytes from sheep inoculated 14 days, but not 7 days previously with bluetongue virus into their monozygotic twin resulted in some protection from challenge with bluetongue virus. T cell enrichment of the 14 day thoracic duct lymphocyte population resulted in a similar effect, indicating the T cell basis of the observed protection. Animals recovered from infection with bluetongue virus type 3 and which received thoracic duct lymphocytes from an identical twin recently infected with the same bluetongue virus type were protected from challenge with bluetongue type 4. These observations suggest that T lymphocytes play an important role in protection against bluetongue virus.