Impact of physical manipulation on in vitro and in vivo release profiles of oxycodone DETERx®: An extended-release, abuse-deterrent formulation

Ernest A. Kopecky, Alison B. Fleming, Patrick K. Noonan, MPharm Ravi K. Varanasi, BS Michael Grima, Saïd Saïm, BS Stephen P. Mayock

Journal of Opioid Management · 2014 · 32 citations · 8 references

Abstract

These mechanical manipulation and PK studies demonstrated that DETERx beads retained their ER properties after mechanical tampering and chewing by study subjects.

References

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