Enzymatic Synthesis of Phenolic CoAs Using 4-Coumarate:coenzyme A Ligase (4CL) from Rice

Abstract

The enzyme, 4-coumarate:CoA ligase (4CL) catalyzes theconversion of 4-coumaric acid into coumaroyl-CoA and afew related substrates into their corresponding products suchas cinnamoyl-CoA, caffeoyl-CoA, and feruloyl-CoA in a pro-cess utilizing ATP and thus channels the common, phenyl-alanine-derived building block into the widely distinct branchesof general phenylpropanoid metabolism.