Concepedia

Plasma Endotoxin and Serum Cytokine Levels in Patients With Alcoholic Hepatitis: Relation to Severity of Liver Disturbance

Masao Fujimoto, Masahito Uemura, Yoshihiro Nakatani, Shigenobu Tsujita, Kazushige Hoppo, Taikoo Tamagawa, Hiroyuki Kitano, Masaji Kikukawa, Tatsuichi Ann, Yoshinobu Ishii,

Alcoholism Clinical and Experimental Research · 2000 · 183 citations · 29 references

DOI

Abstract

Endotoxemia and related elevation of IL-8 may play an important role in the activation and migration of neutrophils in patients with alcoholic hepatitis. Marked elevation of inflammatory cytokines, IL-6 and IL-8, are related to severity and poor prognosis of alcoholic hepatitis. Serum LBP may serve as an index of inflammatory reaction in alcoholics.

References

29

Structure and Function of Lipopolysaccharide Binding Protein

Ralf R. Schumann, Steven R. Leong, Gail W. Flaggs et al. · Science · 1990 · 1.7K citations

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Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

Jack Gauldie, Carl D. Richards, D.C. Harnish et al. · Proceedings of the National Academy of Sciences · 1987 · 1.6K citations · Full text

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Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients

Alexander Khoruts, Laura Stahnke, Craig J. McClain et al. · Hepatology · 1991 · 550 citations

Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess

C. Bode, Valérie Kugler, J. Christian Bode · Journal of Hepatology · 1987 · 540 citations

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Increased Plasma Tumor Necrosis Factor in Severe Alcoholic Hepatitis

George Bird · Annals of Internal Medicine · 1990 · 469 citations