Publication | Open Access
Anthocephaline, a New Indole Alkaloid and Cadambine, a Potent Inhibitor of DNA Topoisomerase IB of <i>Leishmania donovani</i> (LdTOP1LS), Isolated from <i>Anthocephalus cadamba</i>
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Citations
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References
2015
Year
Potent InhibitorAntiparasitic AgentChemical BiologyIsolated AlkaloidsPharmaceutical ChemistryVisceral LeishmaniasisMolecular PharmacologyMedicinal ChemistryPhytopharmacologyDna Topoisomerase IbAnthocephalus CadambaBiochemistryAfrican TrypanosomiasisParasitic ProtozoaBioassay-guided IsolationNeuropharmacologyPharmacologyNew Indole AlkaloidNatural SciencesHerbal MedicinePhytochemistryMedicineDrug Discovery
Chemical investigation of the stem bark of Anthocephalus cadamba has resulted in the isolation of anthocephaline (1), a new indole alkaloid, along with strictosamide (2), vincosamide (3) and cadambine (4). The structures of the isolated alkaloids (1-4) were established by detailed 2D NMR spectral analysis. Cadambine (4) exhibited potent DNA topoisomerase IB inhibitory activity.
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