PubMed · 1971 · 20 citations · 0 references
PharmacyPhysiologyToxicologyToxicodynamicsToxicologic PathologyVentilationEdemaInterstitial Lung DiseaseOxygen EffectPulmonary PhysiologyPulmonary ToxicityPulmonary ToxicologyLong-term Exposure EffectsMechanisms Of Lung ToxicityPleural Space AnatomyPulmonary Endothelial InjuryPulmonary Epithelial InjuryRespiratory Epithelium InjuryUltrastructural CharactersUltrastructural Pathology
The pathogenesis of oxygen toxicity in the lung of rats was studied by electron microscopy. The following long-term effects were established: (1) a progressive destruction of the blood-air barrier beginning with the endothelial cell layer; (2) a profuse edema in the interstitial spaces in the pleural space in the alveoli and in the cytoplasm and organelles; (3) a continuing increase in the quantity and complexity of the alveolar exudate; (4) gradual hemolysis of red blood cells; and (5) eventual subsiding of the interstitial edema in surviving rats with a concomitant development of emphysema.