Immunogenicity of Extended mRNA SARS-CoV-2 Vaccine Dosing Intervals

Abstract

Standard dosing intervals for BNT162b2 and mRNA-1273 SARS-CoV-2 vaccines are 21 and 28 days, respectively. 1 Data suggest improved effectiveness of ChAdOx1 adenoviral 2 and other nonreplicating vaccines 3 with increased dosing intervals, but little data exist for mRNA vaccines. This study investigated the immunogenicity of extended mRNA vaccine dosing intervals.