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Publication | Open Access

<i>In vitro-in vivo</i> availability of metformin hydrochloride-PLGA nanoparticles in diabetic rats in a periodontal disease experimental model

DOIFull Paper Access

19

Citations

16

References

2021

Year

Aline de Sousa Barbosa Freitas Pereira, Maria Laura de Souza Lima, Arnóbio Antônio da Silva-Júnior, Emanuell dos Santos Silva, Raimundo Fernandes de Araújo Júnior, Agnes Andrade Martins, Jovelina Samara Ferreira Alves, Artur de Santana Oliveira, Leandro De Santis Ferreira, Emily Cintia Tossi de Araújo Costa,
Pharmaceutical Biology

Abstract

The formulation modifies pharmacokinetics parameters such as apparent distribution volume and mean residence time. The PLGA + Met 10 mg/kg had a slower elimination rate compared to Met 100 mg/kg in diabetic rats in a periodontal disease experimental model.

References

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