Complexity of Genomic Epidemiology of Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Isolates in Colombia Urges the Reinforcement of Whole Genome Sequencing-Based Surveillance Programs

Abstract

The study outlines complex CRKP epidemiology in Colombia. CG258 expanded clonally and carries specific carbapenemases in specific MGEs, while the other high-risk clones (CG147, CG307, and CG152) present a more diverse complement of carbapenemases. The specifics of the Colombian situation stress the importance of WGS-based surveillance to monitor evolutionary trends of sequence types (STs), MGE, and resistance and virulence genes.