Concepedia

Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3

Jin Yu, Zhenxia Li, Yanran Wu, Hairui Li, Zhen Liu, Lu Liu, Ningjuan Ouyang, Ting Zhou, Bing Fang, Lunguo Xia

Journal of Inflammation Research · 2021 · 34 citations · 36 references

DOIFull text

Open access

Abstract

Through the combination of in vitro FSS model and in vivo UAC model, KMT2B-H3K4me3-ZBTB20 axis was first identified in aberrant FSS-induced cartilage pathogenesis, which may provide evidences for epigenetic-based therapy in the future.

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