Anti-Ageing Ability of Terminalia Species with Special Reference to Hyaluronidase, Elastase Inhibition and Collagen Synthesis In Vitro.

Abstract

Hydroalcoholic extracts prepared from bark of Terminalia arjuna and dried fruit rinds of Terminalia chebula were examined for their effects on enzyme Hyaluronidase and Elastase activity. The extracts were also studied for the effect on fibroblast proliferation and collagen synthesis in vitro. Both the extracts showed to inhibit enzyme Hyaluronidase and Elastase in a dose dependent manner. In addition to their antielastase and antihyaluronidase effect, the same concentrations of the extracts also stimulated fibroblast proliferation and synthesis of total soluble collagen in vitro. These results suggest potential of Terminalia extracts for facilitating delay in skin aging. These extracts not only provide an active ingredient that inhibits hyaluronidase and elastase enzymatic activities, but also to provide the necessary supplies for the cells to maintain and promote their proliferation and to produce their constituents like collagen.