Chemical Communications · 2021 · 118 citations · 22 references
PharmacyMedicinal ChemistryOncologyDrug DiscoveryMolecular OncologyProdrug DesignAnticancer Prodrug DesignHypoxia AdaptationTumor-activated ProdrugsTyrosine Kinase InhibitorsDegradationEpidermal Growth Factor Receptor InhibitionEpidermal Growth Factor Receptor SignalingHypoxia-induced SignalingTumor Microenvironment HypoxiaTumor Microenvironment-responsive ProdrugsTumor-microenvironment Activated ProdrugsTumor-microenvironment-responsive Prodrugs
in hypoxia than in normoxia in HCC4006 cells. This is the first example of identifying a PROTAC to selectively act on tumors utilizing the characteristic of tumor hypoxia and provides a new approach for PROTAC development.
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Light-Induced Protein Degradation with Photocaged PROTACs
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Light-induced control of protein destruction by opto-PROTAC
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