The immunomodulatory effect of microglia on ECM neuroinflammation via the PD‐1/PD‐L1 pathway

Abstract

The appropriate enhancement of the PD-1/PD-L1 pathway in the early stage of ECM has an obvious protective effect on the maintenance of immune microenvironment homeostasis in the brain. Regulating microglia and the PD-1/PD-L1 pathway could be considered as a promising approach for protection against human cerebral malaria in the future.