Concepedia

Intravitreal HDAC Inhibitor Belinostat Effectively Eradicates Vitreous Seeds Without Retinal Toxicity In Vivo in a Rabbit Retinoblastoma Model

Jessica V. Kaczmarek, Carley M. Bogan, Janene Pierce, Yuankai K. Tao, Sheau‐Chiann Chen, Qi Liu, Xiao Liu, Kelli L. Boyd, M. Wade Calcutt, Thomas M. Bridges,

Investigative Ophthalmology & Visual Science · 2021 · 23 citations · 48 references

DOIFull text

Open access

Abstract

Molecularly targeted inhibition of HDACs with intravitreal belinostat was equally effective as standard-of-care melphalan but without retinal toxicity. Belinostat may therefore be an attractive agent to pursue clinically for intravitreal treatment of retinoblastoma.

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