Concepedia

Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca <sup>2+</sup> signaling during T cell activation

Feng Gu, Aileen Krüger, Hannes Roggenkamp, Rick Alpers, Dmitri Lodygin, Vincent Jaquet, Franziska Möckl, Lola C. Hernandez, Kai J Winterberg, Andreas Bauche,

Science Signaling · 2021 · 54 citations · 41 references

DOIFull text

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Concepts

Abstract

signaling between 4 and 12 min after stimulation. Our findings suggest that a DUOX2- and G6PD-catalyzed redox cycle rapidly produces and degrades NAADP through NAADPH as an inactive intermediate.

References

41

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration

Kow Essuman, Daniel W. Summers, Yo Sasaki et al. · Neuron · 2017 · 638 citations · Full text

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The redox state of free nicotinamide–adenine dinucleotide phosphate in the cytoplasm of rat liver

Richard L. Veech, L. V. Eggleston, H. A. Krebs · Biochemical Journal · 1969 · 565 citations · Full text

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A Derivative of NADP Mobilizes Calcium Stores Insensitive to Inositol Trisphosphate and Cyclic ADP-ribose

Hon Cheung Lee, Robert Aarhus · Journal of Biological Chemistry · 1995 · 475 citations · Full text

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Ultrasensitive Genetically Encoded Indicator for Hydrogen Peroxide Identifies Roles for the Oxidant in Cell Migration and Mitochondrial Function

Valeriy V. Pak, Daria Ezeriņa, O. G. Lyublinskaya et al. · Cell Metabolism · 2020 · 435 citations · Full text

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ADP-ribosyl Cyclase and CD38 Catalyze the Synthesis of a Calcium-mobilizing Metabolite from NADP+

Robert Aarhus, Richard Graeff, Deborah M. Dickey et al. · Journal of Biological Chemistry · 1995 · 416 citations · Full text

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