20:T4a4,Molecular diffusion and microcirculation in the capillary network result in a distribution of phases in a single voxel in the presence of magnetic field gradients. This distribution produces a spin-echo attenuation. The authors have developed a magnetic resonance (MR) method to image such intravoxel incoherent motions (IVIMs) by using appropriate gradient pulses. Images were generated at 0.5 T in a high-resolution, multisection mode. Diffusion coefficients measured on images of water and acetone phantoms were consistent with published values. Images obtained in the neurologic area from healthy subjects and patients were analyzed in terms of an apparent diffusion coefficient (ADC) incorporating the effect of all IVIMs. Differences were found between various normal and pathologic tissues. The ADC of in vivo water differed from the diffusion coefficient of pure water. Results were assessed in relation to water compartmentation in biologic tissues (restricted diffusion) and tissue perfusion. Nonuniform slow flow of cerebrospinal fluid appeared as a useful feature on IVIM images. Observation of these motions may significantly extend the diagnostic capabilities of MR imaging.21:T496,Chemodynamic therapy (CDT) utilizes iron-initiated Fenton chemistry to destroy tumor cells by converting endogenous H₂ O₂ into the highly toxic hydroxyl radical (^. OH). There is a paucity of Fenton-like metal-based CDT agents. Intracellular glutathione (GSH) with ^. OH scavenging ability greatly reduces CDT efficacy. A self-reinforcing CDT nanoagent based on MnO₂ is reported that has both Fenton-like Mn²⁺ delivery and GSH depletion properties. In the presence of HCO₃^- , which is abundant in the physiological medium, Mn²⁺ exerts Fenton-like activity to generate ^. OH from H₂ O₂ . Upon uptake of MnO₂ -coated mesoporous silica nanoparticles (MS@MnO₂ NPs) by cancer cells, the MnO₂ shell undergoes a redox reaction with GSH to form glutathione disulfide and Mn²⁺ , resulting in GSH depletion-enhanced CDT. This, together with the GSH-activated MRI contrast effect and dissociation of MnO₂ , allows MS@MnO₂ NPs to achieve MRI-monitored chemo-chemodynamic combination therapy.22:T538,Despite regulation of the reactive oxygen species (ROS) level is an intelligent strategy for cancer therapy, the therapeutic effects of ROS-mediated therapy (including photodynamic therapy (PDT) and chemodynamic therapy (CDT)) are limited by oxygen reliance, inherent flaws of traditional photosensitizers, and strict reaction conditions of effective Fenton reaction. Herein, we reported biocompatible copper ferrite nanospheres (CFNs) with enhanced ROS production under irradiation with a 650 nm laser through direct electron transfer and photoenhanced Fenton reaction and high photothermal conversion efficiency upon exposure to an 808 nm laser, exhibiting a considerable improved synergistic treatment effect. Importantly, by exploiting the properties of O₂ generation and glutathione (GSH) depletion of CFNs, CFNs relieve the hypoxia and antioxidant capability of the tumor, achieving photoenhanced CDT and improved PDT. The high relaxivity of 468.06 mM^-1 s^-1 enables CFNs to act as an outstanding contrast agent for MRI in vitro and in vivo. These findings certify the potential of such "all in one" nanotheranostic agent integrated PDT, photoenhanced CDT, photothermal therapy (PTT), and MRI imaging capabilities along with modulating the tumor microenvironment function in theranostics of cancer.23:T551,Medical imaging is routine in the diagnosis and staging of a wide range of medical conditions. In particular, magnetic resonance imaging (MRI) is critical for visualizing soft tissue and organs, with over 60 million MRI procedures performed each year worldwide. About one-third of these procedures are contrast-enhanced MRI, and gadolinium-based contrast agents (GBC

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