Biochemistry · 2021 · 19 citations · 37 references
Life SciencesBiochemistryMolecular BiologyEnzyme MechanismEnzymologyMetabolic RegulationAmino Acid MetabolismEnzyme InhibitionEnzyme KineticsMichaelis-menten KineticsNicotinamide Adenine Dinucleotide MetabolismIsothermal Titration CalorimetryKinetic StabilityMethionine MetabolismProduct InhibitionProduct Inhibition KineticsS-adenosyl-l-methionine CatalysisS-adenosyl-l-methionine ChemistryS-adenosylmethionine Metabolism
of 6 ± 1 nM). Finally, we found that while Mat2A is unstable at low concentrations (<100 nM), rapidly losing activity at 37 °C, it retained full activity for at least 2 h when Mat2B was present at the known 2:1 Mat2A/Mat2B stoichiometry.
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The U6 snRNA m 6 A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention
Kathryn E. Pendleton, Beibei Chen, Kuanqing Liu et al. · Cell · 2017 · 1.1K citations · Full text