Detection and Predictors of anti-SARS-CoV-2 Antibody Levels in COVID-19 Patients at 8 Months After Symptom Onset

Abstract

<b>Aim:</b> To determine SARS-CoV-2 specific IgM and IgG levels of patients with COVID-19 at 8 months after symptom onset and to explore the predictors of antibody levels. <b>Materials & methods:</b> The magnetic chemiluminescence method was used to measure the antibody levels. Clinical data were collected and analyzed retrospectively. <b>Results:</b> A total of 54 patients were enrolled in this study, of whom 59.3% were IgM positive and 96.4% were IgG positive. The multiple linear regression analysis revealed that the duration of RNA shedding, C-reactive protein level and disease severity were independent predictors of IgG levels. <b>Conclusion:</b> COVID-19 patients retained long-term viral-specific protective immunity. Disease severity, C-reactive protein level and duration of RNA shedding were related to antibody levels 8 months after symptom onset.