Isolation, chemical characterization, and anti-inflammatory activity of coumarins, flavonoids, and terpenes from <i>Tagetes lucida</i>

Abstract

<i>Tagetes lucida</i> is widely used in traditional Mexican medicine for several disorders, including those associated with inflammation. In this work, fifteen compounds were identified (<b>1</b>-<b>15</b>) from <i>T. lucida</i>. Some of these compounds (<b>1</b>-<b>8</b>, <b>10</b>, <b>12</b>-<b>14</b>) were detected for the first time in the plant, and quercetagetin 7-<i>O</i>-β-(6''-Protocatecoyl) glucopyranoside (<b>13</b>) has been identified for any plant species. The inflammation inhibition effects of these compounds were as follows: Amix (<b>1</b>-<b>2</b>) > <b>10 </b>><b> 12a</b> > <b>13 </b>><b> 14a</b> > Bmix (<b>3</b>-<b>9</b>) > <b>12</b>; <b>12</b> and <b>13</b> showed a dose-response behavior. The mixture of <b>14</b> and <b>15</b> was not active. This work contributes to the knowledge of the anti-inflammatory capacity of <i>T. lucida</i> and the chemical identity of their bioactive compounds.