Concepedia

CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis

Xiaoxun Li, Yajun Liang, Cheng Lian, Fangli Peng, Yansen Xiao, Yunfei He, Chengxin Ma, Yuan Wang, Peiyuan Zhang, Yuhan Deng,

Theranostics · 2021 · 67 citations · 29 references

DOIFull text

Open access

Concepts

Abstract

These findings reveal the CST6-CTSB-SPHK1 signaling axis in osteoclast differentiation and provide a promising approach to treat bone diseases with CST6-based peptides.

References

29

Cancer statistics, 2019

Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2019 · 21K citations · Full text

, , +16

A multigenic program mediating breast cancer metastasis to bone

Yibin Kang, Peter M. Siegel, Weiping Shu et al. · Cancer Cell · 2003 · 2.6K citations · Full text

, , +9

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

Neil D. Rawlings, A. John Barrett, Alex Bateman · Nucleic Acids Research · 2011 · 1.6K citations · Full text

, , +15

The clinical course of bone metastases from breast cancer

RE Coleman, RD Rubens · British Journal of Cancer · 1987 · 1.1K citations · Full text

, , +16

<i>MEROPS</i>: the database of proteolytic enzymes, their substrates and inhibitors

Neil D. Rawlings, Matthew A. Waller, A. John Barrett et al. · Nucleic Acids Research · 2013 · 874 citations · Full text

, , +15