Photoredox-Catalyzed Difunctionalization of Unactivated Olefins for Synthesizing Lactam-Substituted <i>gem</i>-Difluoroalkenes

Abstract

Herein, the synthesis of lactam-substituted <i>gem</i>-difluoroalkenes has been developed through a photoredox-catalyzed radical cascade reaction. This developed photoredox-catalyzed, Brønsted base-assisted intramolecular 5-exo-trig cyclization/intermolecular radical addition/β-fluoride elimination reaction offers a simple method for producing lactam, carbamate, or urea-substituted <i>gem</i>-difluoroalkenes with good functional group tolerance and high yields.