Concepedia

TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy

Kathleen M. Schoch, Ethan G. Geier, Eliana Marisa Ramos, Aurora Scrivo, Kathy H. Li, Andrea R. Argouarch, Elisabeth E. Mlynarski, Beth A. Dombroski, Michael DeTure, Dennis W. Dickson,

Science Advances · 2021 · 51 citations · 47 references

DOIFull text

Open access

Concepts

Abstract

haploinsufficiency as a genetic model for tauopathies. In addition, these findings promote tau acetylation as a rational target for tauopathy therapeutics and diagnostic.

References

47

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

Scott W. Rogers, Rodney Wells, Martin Rechsteiner · Science · 1986 · 2.6K citations

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Dissection of the Autophagosome Maturation Process by a Novel Reporter Protein, Tandem Fluorescent-Tagged LC3

Shunsuke Kimura, Takeshi Noda, Tamotsu Yoshimori · Autophagy · 2007 · 2.3K citations · Full text

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Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

Matt Baker, Ian R. Mackenzie, Stuart Pickering‐Brown et al. · Nature · 2006 · 2.1K citations

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Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

Yingsha Zhang, ChangHui Pak, Yan Han et al. · Neuron · 2013 · 1.8K citations · Full text

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A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

Eric Campeau, Victoria E. Ruhl, Françis Rodier et al. · PLoS ONE · 2009 · 1K citations · Full text

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