Genetics and Clinical Characteristics of PPARγ Variant-Induced Diabetes in a Chinese Han Population

Abstract

The prevalence of PPARG-DM is similar in Caucasian and Chinese populations, and DKD was often observed in these patients. Patients with variants in the AF1 of <i>PPARγ2</i> had milder clinical phenotypes and lack typical lipodystrophy features than those with variants in other domains. Our findings emphasize the importance of screening such patients <i>via</i> genetic testing and suggest that thiazolidinediones might be a good choice for these patients.