⁶⁸Ga-DOTATOC PET/CT to detect immune checkpoint inhibitor-related myocarditis

Abstract

The use of ⁶⁸Ga-DOTATOC PET/CT along with immune correlates is a highly sensitive method to detect ICI-related myocarditis especially in the early stage of myocardial inflammation, as patients with elevated cTnI may present normal CMR imaging results. ⁶⁸Ga-DOTATOC PET/CT is also useful for detecting concomitant myositis. These results need to be confirmed in a larger population of patients and validated against a histological gold standard if available.