Concepedia

General stereoretentive preparation of chiral secondary mixed alkylmagnesium reagents and their use for enantioselective electrophilic aminations

Alexander Kremsmair, Henrik R. Wilke, Matthias M. Simon, Quirin Schmidt, Konstantin Karaghiosoff, Paul Knochel

Chemical Science · 2021 · 13 citations · 41 references

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Concepts

Abstract

We report a general method for the preparation of enantiomerically enriched secondary alkylmagnesium reagents, which undergo highly stereoselective transition-metal free electrophilic aminations, leading to α-chiral amines in up to 97% ee.

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