Concepedia

Imperatorin inhibits mitogen‐activated protein kinase and nuclear factor kappa‐B signaling pathways and alleviates neuroinflammation in ischemic stroke

Jianwei Ge, Shiji Deng, Zhiwei Xue, Pinyi Liu, Linjie Yu, Jiangnan Li, Shengnan Xia, Yue Gu, Xinyu Bao, Zhen Lan,

CNS Neuroscience & Therapeutics · 2021 · 29 citations · 44 references

DOIFull text

Open access

Abstract

Imperatorin downregulated MAPK and NF-κB signaling pathways and exerted anti-inflammatory effects in ischemic stroke, which indicated that imperatorin might be a potential compound for the treatment of stroke.

References

44

Heart Disease and Stroke Statistics—2021 Update

Salim S. Virani, Álvaro Alonso, Hugo J. Aparicio et al. · Circulation · 2021 · 5.5K citations · Full text

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*

Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia et al. · Journal of Cerebral Blood Flow & Metabolism · 2020 · 1.2K citations · Full text

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

Li Zhong, Ying Xu, Rengong Zhuo et al. · Nature Communications · 2019 · 395 citations · Full text

Boosting mTOR-dependent autophagy via upstream TLR4-MyD88-MAPK signalling and downstream NF-κB pathway quenches intestinal inflammation and oxidative stress injury

Mingxia Zhou, Weimin Xu, Jiazheng Wang et al. · EBioMedicine · 2018 · 338 citations · Full text

Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke

David Y. Fann, Yun‐An Lim, Yi-Lin Cheng et al. · Molecular Neurobiology · 2017 · 312 citations

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