Life after thyroid cancer: the role of thyroglobulin and thyroglobulin antibodies for postoperative follow-up

Abstract

INTRODUCTION: Differentiated thyroid carcinomas (DTCs) are treated with (near-)total thyroidectomy and radioiodine therapy. Recently, the use of highly sensitive thyroglobulin (hsTg) assays has simplified DTC follow-up and improved patients' quality of life. More limited approaches are currently applied in low-risk patients requiring interpretations of Tg results in different clinical scenarios. Finally, Tg assays are hampered by interference from thyroglobulin autoantibodies (TgAb). AREAS COVERED: The role of Tg measurement in DTC patients treated with complete thyroid ablation, thyroidectomy alone, or lobectomy is summarized. The management of patients carrying positive TgAb is also addressed. EXPERT OPINION: Patients with undetectable hsTg after total thyroid ablation are safely managed by periodic hsTg measurement, combined with selective use of imaging procedures in few cases. Serum hsTg trend remains informative in patients treated without radioiodine ablation. However, reliable reference values are urgently needed in this setting. The role of hsTg is debated in patients who have undergone lobectomy due to the amount of Tg released by a functioning thyroid lobe. The evaluation of TgAb trend over time (i.e. surrogate tumor marker) is recommended in patients with positive TgAb and potentially interfering Tg results.