Population pharmacokinetics of cefepime in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study)

Accurate Detection of Outliers and Subpopulations With Pmetrics, a Nonparametric and Parametric Pharmacometric Modeling and Simulation Package for R

Michael Neely, Michael G. van Guilder, Walter M. Yamada et al. · Therapeutic Drug Monitoring · 2012 · 474 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections

Peggy S. McKinnon, Joseph A. Paladino, Jerome J. Schentag · International Journal of Antimicrobial Agents · 2008 · 465 citations

Veterinary Medicine, Infectious Diseases, Microbiology +16

Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: results from an ex vivo study

Kiran Shekar, Jason A. Roberts, Charles McDonald et al. · Critical Care · 2015 · 243 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +14

Cefepime neurotoxicity in the intensive care unit: a cause of severe, underappreciated encephalopathy

Jennifer E. Fugate, Ejaaz A. Kalimullah, Sara E. Hocker et al. · Critical Care · 2013 · 198 citations · Full text

Pharmacy, Pharmacotherapy, Neurocritical Care +12

High Cefepime Plasma Concentrations and Neurological Toxicity in Febrile Neutropenic Patients with Mild Impairment of Renal Function

Frédéric Lamoth, Thierry Buclin, Andrés Pascual et al. · Antimicrobial Agents and Chemotherapy · 2010 · 181 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacotherapy +14