Nickel-Catalyzed Reductive Csp²–Csp³ Cross Coupling Using Phosphonium Salts

Abstract

A nickel-catalyzed reductive cross coupling with phosphonium salts and allylic C(sp³)-O bond electrophiles, which granted direct construction of the C(sp²)-C(sp³) bond, is successfully developed. The protocol features broad substrate scope, high-functional-group tolerance, and heterocycle compatibility. Notably, the much more challenging reductive cross coupling with heterocyclic thiazolylphosphonium salts has also been accomplished for the first time.