Concepedia

Delayed inhibition of ERK and p38 attenuates neuropathic pain without affecting motor function recovery after peripheral nerve injury

Saisai Huang, YingTing Chen, Yue Jia, Tuo Yang, Wenfeng Su, Zhenyu Zhu, Peng Xue, FeiFan Feng, Yayu Zhao, Gang Chen

Neuropharmacology · 2021 · 29 citations · 27 references

DOI

Concepts

References

27

Spared nerve injury: an animal model of persistent peripheral neuropathic pain

Isabelle Décosterd, Clifford J. Woolf · Pain · 2000 · 2.3K citations

, , +16

ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model

Zhi‐Ye Zhuang, Peter Gerner, Clifford J. Woolf et al. · Pain · 2005 · 778 citations

, , +17

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

Zhonghui Guan, Julia Kuhn, Xidao Wang et al. · Nature Neuroscience · 2015 · 558 citations

, , +16

CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5

Bao‐Chun Jiang, De‐Li Cao, Xin Zhang et al. · Journal of Clinical Investigation · 2016 · 336 citations · Full text

, , +17

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

Sarah Taves, Temugin Berta, Da-Lu Liu et al. · Brain Behavior and Immunity · 2015 · 317 citations

, , +17