Discovery of 1,8-naphthalidine derivatives as potent anti-hepatic fibrosis agents via repressing PI3K/AKT/Smad and JAK2/STAT3 pathways

Activation of the Pro-survival Phosphatidylinositol 3-Kinase/AKT Pathway by Transforming Growth Factor-β1 in Mesenchymal Cells Is Mediated by p38 MAPK-dependent Induction of an Autocrine Growth Factor

Jeffrey C. Horowitz, Daniel Lee, Meghna Waghray et al. · Journal of Biological Chemistry · 2004 · 231 citations · Full text

Life Sciences, Cell Biology, Pathobiology +13

The Phosphatidylinositol 3-Kinase/Akt Pathway Enhances Smad3-stimulated Mesangial Cell Collagen I Expression in Response to Transforming Growth Factor-β1

Constance E. Runyan, H. William Schnaper, Anne-Christine Poncelet · Journal of Biological Chemistry · 2004 · 223 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Transforming Growth Factor β1 (TGF-β1) Promotes Endothelial Cell Survival during In Vitro Angiogenesis via an Autocrine Mechanism Implicating TGF-α Signaling

Francesc Viñals, Jacques Pouysségur · Molecular and Cellular Biology · 2001 · 189 citations · Full text

Life Sciences, Cell Biology, Pharmacology +11

Current status of novel antifibrotic therapies in patients with chronic liver disease

Michal Cohen‐Naftaly, Scott L. Friedman · Therapeutic Advances in Gastroenterology · 2011 · 185 citations · Full text

Medicine, Pathology, Pharmacology +17

Transforming Growth Factor-β (TGF-β)-mediated Connective Tissue Growth Factor (CTGF) Expression in Hepatic Stellate Cells Requires Stat3 Signaling Activation

Yan Liu, Heng Liu, Christoph Meyer et al. · Journal of Biological Chemistry · 2013 · 178 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +11